Anxiety is a common comorbidity in depression patients and buprioprion can dramatically raise anxiety levels

It is a second-line treatment for a reason. Great when it works. Harmful when it does not.

Yeah, this is exactly why I couldn’t stay on it. I already deal with GAD and OCD, and whatever benefits it had for the depression were directly counteracted by the return of acute anxiety.

It was truly hellish. Feeling like I had this energy that I needed to use, while also feeling so anxious that I didn’t want to leave the apartment.

I know it works really well for some people but I was definitely not one of them.

Thank you, that answer makes a lot of sense.

Just want to underscore that this is the right answer.

Doctor gave it to me and I reacted paradoxically to it. Worse depression and even more peculiar I picked up smoking again. I never felt such an urge to smoke in my life. Over the years I've been looking for an explanation for that reaction but wasnt able to find anything

My doctor tried me on Bupropion for ADHD and I think it caused my BorderlinePD to get much worse, so definitely YMMV.

Or Auvelity, which is a newer one that mixes Bupropion and DXM.

It has a long and scary list of side effects, good if it works for you

They all do and my reading has always been that bupronion has less scary side effects than e.g. escalitopram.

There's a medicine named escalate-o-pram?

Probably a misspelling of escitalopram, aka Lexapro.