To give an example: On my home pc I have the snapshots of Opera running with hardware acceleration and WebGL enabled: No problems. A few minutes ago I've installed Opera 12 on my work pc and tried the same. Afterwards I couldn't start Opera anymore and had to reset the options in the config file (AppData\Roaming\Opera\Opera\operaprefs.ini if anyone needs to do the same; EnableWebGL and HardwareAcceleration are the keys).
So: Yeah, it's still a bit buggy at the moment (probably hardware compability issues). I've already send my bug report, hope they fix it soon.