House is an interesting example. He wasn't an asshole because of his genius. He was like that because of chronic pain. And I actually have experienced that myself due to degenerative disc disorder. It is definitely not something you want to emulate. It is actually pretty terrible feeling like your emotions happen only in extremes due to reasons you can't do anything about, being able to step outside of yourself after the fact and see that you are needlessly hurting people you care about, but even knowing that, you can't stop it from happening in the moment.