It made me feel better, as I struggle from time to time with design, to know that even companies with as much focused design talent as 37signals tweak stuff endlessly, and that clean designs don't spring fully-formed from their heads. Everyone iterates.
Agreed. I think iteration is one of the secrets to doing any kind of creative work well, especially design. Too many people get discouraged by their early attempts at a design, because they assume (incorrectly) that being good means getting things right the first time.