Makes sense - I am 71 years old, and when I get really used to software I don't like to change. For example, I am celebrating my 40th anniversary of having paid Common Lisp work. Using Mosh (sometimes) instead of SSH was a worthwhile change though.
Good news that tmux allows to customize bindings, including "leader" key - so I've adjusted my .tmux.conf to have the same bindings as in screen and switching them without enforcing myself (in that rare cases when tmux is not present/cannot be installed on server).