If you still have to come in multiple days per week you now still need to live within a reasonable commuting distance of the office and preferably have a decent home office. Less of an issue if the office is in a suburban office park. More so if it's downtown in a city.

If it's one day per week, it's probably more tractable because you can probably put up with a pretty long commute if need be if it's just once a week.

So the details matter.