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Either can happen. The root cause is growth of Burkholderia gladioli [0] on certain foods rich in specific fatty acids, which include coconut and corn. This can happen during the fermentation process of fermented coconut and corn products if there's Burkholderia gladioli contamination and the pH, salinity and temperature aren't controlled to prevent its growth, but it is also possible for Burkholderia gladioli to contaminate food containing coconut or corn after it has been produced and produce bongkrek acid while it is being stored (e.g. [1], which is where I first learned about this).

Bongkrek acid [2] is odorless, tasteless and is not destroyed by cooking. Food can show no signs of spoilage and contain a lethal dose, though fermented products that were contaminated during production might show differences in color, texture and smell if the Burkholderi out-competed the normal fermentation process.

[0]: https://en.wikipedia.org/wiki/Burkholderia_gladioli

[1]: https://youtu.be/yXnSYfv6bCA?si=7DTW4J0ahMoWUuLd

[2]: https://en.wikipedia.org/wiki/Bongkrek_acid

[3]: https://en.wikipedia.org/wiki/Tempeh#Tempe_bongkr%C3%A8k


I doubt that. Oxide was founded by a bunch of ex-Sun people who have already been burned by the Oracle acquisition. If you read through what they say, their company values, and how they act, it's pretty clear their intent is to grow a sustainable long-term business and they're not looking for an exit.


VC funding is not for "a sustainable long-term business".


We are trying to build a sustainable long-term business! It's just that you need enormous amounts of money to get there when shipping this large a product.

The idea behind VC funding generally is that you need large infusions of capital to get to the point where the business becomes sustainable long-term. The first one is the most expensive, and so on. Hardware is capital-intensive compared to SaaS, and especially so in the current environment.


Read the blog post on their series C [0]. It's not long, but the most relevant excepts are:

> So if we didn’t need to raise, why seek the capital? Well, we weren’t seeking it, really. But our investors, seeing the business take off, were eager to support it. And we, in turn, were eager to have them: they were the ones, after all, who joined us in taking a real leap when it felt like there was a lot more risk on the table.

> ...

> Our intent in starting Oxide was not to be an acquisition target but rather build a generational company; this is our life’s work, not a means to an end. With our Series C, customers don’t have to merely take our word for it: we have the capital to assure our survival into the indefinite future.

Maybe you could read that and think its complete bullshit and they're lying their asses off. Considering the people behind Oxide and their history, that's vanishingly unlikely though.

The reasonable conclusion is that they would not have raised yet more money if it wasn't due to being offered very generous terms by investors who wouldn't threaten the long-term future of the business.

[0]: https://oxide.computer/blog/our-200m-series-c


It says "they've entirely derisked capital" and now ~6 months later they raised twice as much. Lying is a strong word but that post clearly wasn't accurate at the time.

They've raised a lot of money and there will be pressure for an exit sooner rather than later.


I don't think that's necessarily true.

You can be cashflow positive and still benefit from having a larger pool of cash to throw around, particularly in any situation involving hardware manufacturing.

If you tell your investors "our limiting factor is how fast we can spend to deliver on additional requirements for these new customers", then it can both be true that you're not going to miss payroll for 5 years no matter what happens tomorrow and more cash would be beneficial.


No, it's not necessarily true but it is a well trod path.


Look at how much the components cost 6 months ago and now. That may explain why some calculations shifted considerably. It may be an act of keeping up with the market and having some reserve.


Depends on the VC. Some VC's are happy to own great businesses, even long term. Most are definitely vultures after a quick turn around. Mostly it has to do with where the VC gets their funding. Most VC's get their funding from offering a fund with a 2-5 year time-frame. Some are 10 yr funds, and some are long-term funds or are funded by a family office or two, which can be happy with great businesses long term.


Yes, it matters. I found your comment hard to read and had to re-read it a couple of times to parse it. If you want to use the hyphen because it's more easily typed I suggest using the double hyphen "--", which perhaps doesn't have the correct semantics on a per-character basis, but at least looks mostly right and will be clear in meaning to a human reader.


Could you actually explain what you disagree with? In my opinion, everything in the comment you're replying to is obviously correct.

If you're going somewhere where there is a chance you might get lost, injured or trapped by weather, and need rescue, you should already be bringing something like a Garmin inReach. That's a highly ruggedized device with a battery that lasts for over a week without recharge, is small enough to keep in a pocket, provides two-way messaging and weather reports, can track your position at regular intervals so your family can see where you are, and can, without any setup and even when you're seriously injured, be used to directly send out an SOS with automatic reporting of your position and two-way voice communication.

As excellent as Starlink is, it is nowhere near a substitute for those capabilities. And the inReach has existed for longer than Starlink, ergo Starlink doesn't change the risk profile. The only real argument that Starlink changes the risk profile is if you're comparing Starlink vs nothing, or Starlink + PLB vs just PLB. And sure, in those cases Starlink is a significant improvement, but it's still inferior to something like an inReach.

The second part of the argument is that having better connectivity is no substitute for fundamentals, which is overwhelmingly, obviously correct. Yes, bring all the connectivity you want, the more the better if you're willing to carry it. But your plan shouldn't be built around the assumption that you can be rescued if things go wrong. If you get complacent due to having better connectivity it's entirely possible for it to worsen, rather than improve, your risk profile.


There are infinite examples.

Right now I am in an overlanding vehicle, but I'm not an expert in offroading. I drove down a 5 mile trail that was very technical. The car can handle it, but it needs caution and the way back is much harder. I was extremely hesitant about going back up that way. If I get stuck, I am solo and I am hours from town via driving. So I just pulled out starlink, and with a combination of claude, off roading websites, and google maps, found an easier, roundabout, and more off the grid way back.

At every step I can use available information to put myself onto safer routes, I can research every decision before I make it. Where is the safest place to sleep, etc.

Pre internet people are out there just winging it in the back country


One would argue that pre-Internet people prepared more, started on easier trails or went out with experienced people first.


My generation would prepare in advance for outing. We’d print the route from MapQuest. ;)


And MapQuest would show you that the suggested route is probably too dangerous to return on off-road?


The track you chose has always had the same risk, you did it anyway even with all that technology beforehand. Congrats, you are the example I’m referring to.


You've got that completely backwards. Correctly applying Bayes' theorem, if an anomaly is observed you incorporate the prior into the calculation of the posterior probability. You don't just give up and say "the prior is miniscule so the likelihood is useless".

And then, even that's not enough. Decision theory needs to be applied to decide what action to take. That means taking into account the expected QALYs, cost and inconvenience across the distribution of possible outcomes. There's a whole spectrum of possible decisions, from immediately performing surgery, performing an invasive test like a biopsy, performing other less invasive tests, scheduling a follow-up non-invasive test at a later date, or just following a regular schedule of non-invasive tests and looking for any evolution along a longer time period.

The real problem is the binary thinking of either "we think you have X" and therefore tests must be performed or "we think you don't have X" and therefore tests shouldn't be performed. If medical organizations adopted empirically grounded decision frameworks, by applying them consistently doctors would be able to see something anomalous, assess that the risk isn't high enough to warrant immediate investigation, and be protected from a lawsuit in the unlikely case it was, in fact, something. And then we could do away with this "if we look we might find something" nonsense, which is pure fallacy.


You can look at the Wikipedia page on railway defect dectectors [0].

Under "rail break monitors" it mentions both electrical continuity and time-domain reflectometry can be used, and are most frequently used on high-speed tracks.

In addition, there are vast array of other detectors using acoustic sensors, strain gauges, accelerometers, cameras in the visible and infrared spectrum or laser measurement, that potentially could have detected an anomaly (i.e. damage to the wheels of other trains before the incident).

[0]: https://en.wikipedia.org/w/index.php?title=Defect_detector


That's not what "hot" means in this context. "Hot" means "highly radioactive", i.e. high number of decay events per second, high concentration of short half-life isotopes, high power/volume resulting from radioactive decay.

Nuclear reactors do not work off radioactive decay. U-235, for example has a half life of 704 million years. Radioisotope thermal electric generators [0] by contrast do run off radioactive decay, an isotopes used for that application have short half-lives, such as Pu-238 with 87.7 years.

Commercial nuclear reactors use unenriched or minimally enriched fuel. This means that, within a fairly short period of time, the percentage of fissile material in the fuel drops to the point where continuing to use it is no longer economical. At that point the fuel is a mixture of extremely hot fission products, transuranics, unreacted fuel, and non-fissile (but fertile) isotopes such as U-238.

It's not practical to use the decay energy from the fission products for power. What would make much more sense would be to remove the fission products and recycle the fuel that remains into new fuel (for a reactor that's designed to use it). This would be a much more efficient use of mined nuclear fuel (allowing nuclear power to be used for thousands of years), it would vastly reduce the volume of nuclear waste, and it would mean nuclear waste would only be hazardous for decades to centuries.

The US was on the path to this with the Integral Fast Reactor and Pyroprocessing [1] developed by the Argonne National Laboratory. This was killed [2] in 1994 by the Clinton administration. Not for any technical reason, but because it was a "threat to nuclear non-proliferation". How that makes sense when, to the best of my knowledge the process developed by Argonne couldn't be used to produce weapons-grade material, and even if it could the US already had nuclear weapons so it wouldn't be proliferating it to a non-nuclear country, I don't know. But, apparently, since some other forms of nuclear waste reprocessing can be used to generate weapons-grade material (by extracting Pu-239), it was a bad symbol so it had to go.

[0]: https://en.wikipedia.org/wiki/Radioisotope_thermoelectric_ge...

[1]: https://en.wikipedia.org/w/index.php?title=Integral_fast_rea...

[2]: https://en.wikipedia.org/w/index.php?title=Integral_fast_rea...



Your question is rather ambiguous. Do you mean using chemistry to develop new techniques or combine unusual ingredients to create food that has novel flavors or textures? That would fall under Molecular Gastronomy, which has been highly influential within fine dining in the last few decades.

Do you mean processing ingredients with the goal to take cheap ingredients and make a product as hyper-palatable as possible? That would generally be called "ultra-processed food"; you're not going to find a Doritos chip in nature.

Do you mean developing completely completely new flavors via chemical synthesis? I don't think there's much possibility there. Our senses have evolved to detect compounds found in nature, so it's unlikely a synthetic compound can produce a flavor completely unlike anything found in nature.

Also, I think you're overestimating jelly. Gelatine is just a breakdown product of collagen. Boil animal connective tissue, purify the gelatine, add sugar and flavoring and set it into a gel. It's really only a few of techniques removed from nature. If you want to say it's not found in nature, then fair enough, but neither is a medium-rare steak.


I mean using chemistry to create food using atypical ingredients that aren't normally classified as food or entirely synthetic. Take more simpler or more abundant compounds to create original food instead of using plants and wildlife. Flavors don't need to be new, but as others mentioned there are plenty of recently invented flavors. Doritos is ultra-processed corn, what i'm saying is Doritos but there is no corn involved. The original article is about meat-like food, I was saying "why meat-like" , if it is food that has similar taste like meat, that's fine, but it doesn't need to be like meat, it just needs to taste good and have palatable texture. Maybe we can have something tastes better than meat!


Have you seen the presentation from GDC 2017 on the architecture of Overwatch [0]? If you watch the video in detail -- stepping through frame-by-frame at some points -- it provides a nearly complete schematic of the game's architecture. That's probably why the video has since been made unlisted.

[0]: https://www.youtube.com/watch?v=W3aieHjyNvw


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